Optimizing amino acid metabolism is crucial for bettering protein utilization, minimizing nitrogen excretion, and preserving protein feed assets. Supplementation with niacinamide (NAM) has demonstrated useful results by decreasing nitrogen emissions and selling progress efficiency in pigs.
Goal: This research aimed to research the consequences of including 360 mg/kg NAM to diets on nutrient metabolism, offering insights into how dietary NAM supplementation enhances nitrogen utilization and progress efficiency in pigs.
Strategies: Forty growing-finishing pigs have been randomly assigned to certainly one of 4 experimental diets as follows: 1) basal food plan + 30 mg/kg NAM (management); 2) basal food plan + 360 mg/kg NAM; 3) low-protein food plan + 30 mg/kg NAM, and 4) low-protein food plan + 360 mg/kg NAM for 11 weeks. On the finish of the experimental interval, blood, liver, ileal digesta, and mucosa samples have been collected.
Outcomes: Supplementation of each the management and low protein diets with 360 mg/kg NAM resulted in decreased urea nitrogen concentrations and carbamyl phosphate synthetase-I exercise. The pyruvate dehydrogenase exercise within the serum and liver, in addition to the exercise of pyruvate dehydrogenase, citrate synthase, and glutamate dehydrogenase 1 within the ileum mucosa, was elevated by supplementing the low protein food plan with 360 mg/kg NAM. The low protein food plan with 360 mg/kg NAM elevated the villi size to crypt depth, mRNA expression of glucose transporters 1 and a pair of and alanine-serine-cysteine transporter 1, and mRNA expression of mechanistic goal of the rapamycin 1 within the ileum. Moreover, 360 mg/kg NAM supplementation within the low protein food plan decreased ileal Lactobacillus abundance (LDA > 4) and elevated ileal microbial nucleotide and purine metabolism.
Conclusion: The addition of 360 mg/kg NAM to the low protein food plan decreased urea manufacturing within the liver, enhanced glucose and amino acid absorption and transport within the ileum, and improved glucose metabolism.
Lengthy X, Wei H, Wang Z, Tang Z, Xu Y, Peng X, Solar Z, Wu L. Impacts of 360 mg/kg Niacinamide Supplementation in Low-Protein Diets on Power and Nitrogen Metabolism and Intestinal Microbiota in Rising–Ending Pigs. Animals. 2025; 15(14): 2088.
https://doi.org/10.3390/ani15142088
