Constipation and systemic irritation are widespread in late pregnant and lactating sows, which trigger well being issues like uteritis, mastitis, dystocia, and even stillbirth, additional influencing piglets’ survival and progress. Probiotic supplementation can enhance similar to points, however the useful mechanism of relieving constipation and enhancing intestine motility stays underexplored. This research aimed to research the results and mechanism of probiotic supplementation in consuming water to late pregnant sows on constipation, irritation, and piglets’ progress efficiency.
Strategies: Seventy-four sows had been randomly allotted to probiotic (n = 36) and management (n = 38) teams. The intestinal exercise of the sows was monitored at six completely different time factors, i.e., between 100 days of gestation (G100d, G106d, and G113d) and 23 days of lactation (L6d, L13d, and L19d). Sows’ feces had been qualitatively evaluated earlier than the every day morning cleansing session and blood and fecal samples of sows had been collected at G100d, G113d, and L23d.
Outcomes: Probiotic therapy considerably relieved sow constipation, enhanced serum IL-4 and IL-10 ranges whereas decreasing serum IL-1β, IL-12p40, and TNF-α ranges, and elevated piglet every day achieve and weaning weight. Moreover, probiotic administration reshaped the sow intestine bacteriome and phageome construction/variety, accompanied by will increase in some doubtlessly useful micro organism. At 113 days of gestation, the probiotic group was enriched in a number of intestine microbial bioactive metabolites, a number of carbohydrate-active enzymes that degrade pectin and starch, fecal butyrate and acetate, and a few serum metabolites concerned in vitamin and amino acid metabolism.
Conclusion: The probiotic results had been doubtless achieved by orchestrated responses of the intestine bacteriome, phageome, and bioactive metabolites, in addition to colonic and systemic metabolism within the late gestation sows.
Ma T, Huang W, Li Y, Jin H, Kwok L Y, Solar Z, Zhang H. Probiotics alleviate constipation and irritation in late gestating and lactating sows. npj Biofilms and Microbiomes. 2023; 9(1): 70.
https://doi.org/10.1038/s41522-023-00434-z
