Goal: On the idea that Hungatella hathewayi (HH) could have potential advantages for swine replica, the target of this examine was to analyze the consequences of HH supplementation on sows’ hormone ranges, antioxidant capability, host metabolism, and intestine microbiota.
Strategies: Twenty wholesome Giant-Yorkshire sows with related bodily circumstances have been randomly divided into 4 teams based mostly on the precept of comparable weight (n = 5). The management group was fed a basal weight loss program, whereas the remedy teams acquired the basal weight loss program supplemented with 5 × 1010, 5 × 1011, and 5 × 1012 CFU/sow of HH. Supplementation with HH was administered each three days over a remedy period of 30 days. Serum and feces of sows have been collected on the finish of the experiment.
Outcomes: Dietary HH supplementation considerably elevated the estrogen focus in sows however didn’t alter the degrees of FSH, progestogen, or antioxidative capability (T-AOC, SOD, and MDA). 16S rRNA sequencing indicated that HH remedy altered the intestine microbial composition and metabolism, rising the relative abundance of Roseburia, Alloprevotella, Lachnospira, Anaerovibrio, and Hungatella within the HH group. Additional metabolomic evaluation advised that the differentially gathered metabolites from serum and feces concerned adjustments within the metabolism of pyrimidine and tryptophan, in addition to alterations in steroid hormone biosynthesis.
Conclusion: The dietary supplementation with Hungatella hathewayi has the potential to modulate host estrogen ranges by means of the regulation of intestine microbiota and host metabolism. This mechanism could function a novel and promising method for influencing reproductive efficiency in sows.
Shi Ok, Zhou X, Dai J, Jia J, Dong G, Wang Y, Shen Y, Chen S. Probiotic Hungatella hathewayi will increase host estrogen degree through regulation of intestine microbiota and host metabolism in sows. Frontiers in Microbiology. 2025; 16: 1598365.
https://doi.org/10.3389/fmicb.2025.1598365
