Weaning is a essential section for piglets, usually marked by stress, feed deprivation, and intestine disturbances, which might result in irritation, diarrhea, and impaired progress. Indole-3-propionic acid (IPA) has anti-inflammatory properties, which will be helpful for weaned piglets with underdeveloped immune techniques. The examine explores the impression of IPA supplementation on progress efficiency, oxidative stress, and irritation response in weaned piglets.
Strategies and outcomes: Two experiments have been carried out to check the efficacy of IPA to cut back the likelihood of post-weaning diarrhoea. In Experiment 1, 90 weaned piglets have been divided into six teams (5 replicates per group, 3 pigs per replicate), with every group receiving a basal weight loss program with various quantities of IPA (0, 50, 100, 200, 400, or 600 mg/kg) for 42 d. Piglets fed the diets with 50, 100, and 200 mg/kg of IPA exhibited lowered feed conversion ratios in comparison with the management piglets.
Notably, 50 and 100 mg/kg IPA remedies considerably lowered diarrhea incidence and serum interleukin (IL)-6 content material. Conversely, a excessive dosage of 600 mg/kg IPA led to elevated serum contents of tumor necrosis issue (TNF)-α, and IL-6. Optimum antioxidant advantages have been noticed at 100 mg/kg IPA supplementation, which considerably lowered malondialdehyde ranges whereas enhancing serum whole antioxidant capability and whole superoxide dismutase exercise on d 14.
Experiment 2 investigated the results of IPA on lipopolysaccharide (LPS) problem in weaned piglets. A complete of 32 weaned piglets allotted into 4 teams, with 8 replicates per group and 1 piglet per replicate: a management group, a LPS problem group, a LPS problem group supplemented with 100 mg/kg IPA, and a gaggle supplemented with 100 mg/kg IPA alone.
Upon administration of LPS or saline injection, the outcomes indicated that dietary IPA supplementation in challenged piglets enhanced villus peak: crypt depth, modulated IL-8 and IL-22 mRNA relative expression, and elevated the tight junction protein claudin-1 mRNA relative expression within the intestinal mucosa.
Conclusion: It’s concluded that incorporating IPA into the weight loss program of weaned piglets can successfully enhance their well being and growth.
Ming D, Xu X, Jiang X, Li Y, Solar W, Xiang J, Huang M, Pi Y, Li X. Indole-3-propionic acid enhances progress efficiency and reduces diarrhea by way of modulating redox standing and intestinal irritation in weaned piglets. Anim Nutr. 2024 Sep 26;19:240-247.
https://doi.org/10.1016/j.aninu.2024.08.004
