Goal: The current examine goals to guage the results of various dietary selenium-enriched yeast (SeY) ranges on intestinal morphology, epithelial mucus manufacturing, antioxidant exercise, and colonic bacterial communities in growing-finishing pigs.
Strategies: Thirty 90 d-old growing-finishing pigs (54.37±2.13 kg) had been randomly assigned to 5 remedy teams. The management group (CON) was fed a basal eating regimen, whereas the opposite 4 teams had been fed the basal eating regimen supplemented with SeY at 0.3, 1, 3, and 5 mg/kg, respectively, for an 80-day of feeding trial. On the finish of the experiment, pigs had been euthanized, and samples from the jejunum, ileum, colon, and feces (day 52 and ultimate day) had been collected.
Outcomes: The outcomes confirmed that the addition of SeY at 0.3 mg/kg elevated villus top, villus top/crypt ratio, and mucus manufacturing within the ileum, as evidenced by the rise in goblet cell quantity and mucus thickness. Moreover, 0.3 mg/kg SeY up-regulated the mRNA expression ranges of the MUC-1, claudin-1, occludin, and ZO-1 genes. In distinction, high-dose SeY at 5 mg/kg leading to harm to mucosal morphology. Ileal antioxidant exercise of SOD and GSH-Px, and jejunal mRNA expression of GPX-1 and GPX-4, had been greater in response to SeY. Faecal Se excretion elevated in SeY teams in a dose-dependent method. SeY led to a major distinction in beta range amongst remedy teams and led to a major lower within the concentrations of isobutyric and isovaleric acids when in comparison with the management group. The acetate, propionate, butyrate, and complete short-chain fatty acids had been positively correlated with the biomarker genera Agathobacter (SeY at 0.3mg/kg), whereas isobutyrate and isovalerate had been negatively correlated with biomarker genera Lactobacillus (SeY at 0.3mg/kg). Fecal accumulation of Se was positively correlated with the biomarker genera Alloprevotella (SeY at 3mg/kg) and Prevotellaceae_UCG-001 (SeY at 5mg/kg) and was negatively correlated with biomarker genera Agathobacter (SeY at 0.3mg/kg), Bacteroides (CON), and Faecalibacterium (CON).
Conclusion: SeY doses of 0.3 mg/kg have helpful results on intestinal well being, whereas extended SeY doses as much as 5 mg/kg could compromise the intestinal mucus operate in growing-finishing pigs.
Su L, Yi H, Xu E, Xiao M, Gao Y. Colonic bacterial group responding to selenium-enriched yeast supplementation related to improved intestine mucus operate in growing-finishing pigs. BMC microbiology. 2025; 25(1): 213. https://doi.org/10.1186/s12866-025-03909-5
