L-malic acid (MA) consumption in sows throughout late gestation may enhance glucose metabolism and enhance myogenin expression within the skeletal muscle of the offspring.
Goal: This examine aimed to research the impression of maternal MA consumption through the crucial interval of skeletal muscle improvement on muscle improvement and metabolic traits in offspring.
Strategies: At day 30 of gestation, 45 Landrace × Yorkshire sows have been divided into 3 teams and acquired both a corn-soybean basal food regimen (management) or the basal food regimen supplemented with 1% or 2% MA complicated. Sows’ serum was collected at day 50 and 90 of gestation. Ranges of irritation markers and myokines have been measured in piglet serum at start and at weaning (21 day-old). The longissimus dorsi muscle was additionally collected to evaluate skeletal muscle progress and improvement. Statistical analyses included t-tests, 1-way or 2-way evaluation of variance.
Outcomes: Dietary MA supplementation lowered irritation and oxidative stress in sows. MA elevated serum insulin-like progress issue 1 by 18.51% and decreased reworking progress issue β1 concentrations by 42.77% in sows, notably at day 50 of gestation. Notably, maternal MA lowered irritation and altered myokine secretion. It additionally elevated paired field 7 expression in piglet skeletal muscle by 74.29% at day 1, and induced muscle fiber-type transition at day 21. That is evidenced by elevated sluggish myosin heavy chain protein concentrations and decreased myosin heavy chain-IIx messenger ribonucleic acid (RNA) concentrations. RNA-sequential evaluation revealed that maternal MA consumption affected the expression of genes concerned in amino acid and fatty acid metabolism within the skeletal muscle of piglets at day 1, whereas inhibiting the Hippo signalling pathway.
Conclusion: Total, the outcomes recommend that maternal MA consumption is a possible technique for remodelling skeletal muscle perform and enhancing metabolic well being in offspring.
Solar H, Miao Q, Wan B, Liao J, Tian N, Chang Z, Yin J, Zhang X. L-malic acid improves the metabolic well being of gestating sows and drives skeletal muscle fiber transforming within the offspring. The Journal of Vitamin. 2025.
https://doi.org/10.1016/j.tjnut.2025.07.018
